Juan Ponce de Leon is thought to have accompanied Christopher Columbus on his voyage to the New World. He also explored present-day Puerto Rico and Florida coast. Francisco Vazquez de Coronado discovered the Grand Canyon and other famous landmarks in the American southwest. Hernando de Soto explored Florida and was the first to discover and cross the Mississippi River.
85% - 95% of Native Americans have died due to disease from Europe, with Europeans exploring the New Continent, and animals being brought over from Europe, most couldn't fight the diseases.