Alexander III of Macedon went east and south in his conquests because of few reasons. The Greeks were already conquered by his father, but he needed to secure his authority there so he made a few big blows for them, especially because the Greeks despised the fact that the Macedonians conquered them.
The most advanced civilizations were on the east, and also they were the most powerful, with the Persian Empire being at the top at that time. Knowing that in order to be able to create a large empire he needs to eliminate the main threat, Alexander went for the Persians and managed to win.
In the south, Egypt was the traditional place of civilization, prosperity, and it had a well established reputation, so Alexander went for it and took it under his control.
He had plans to go westwards towards Rome, but since Rome was nothing special at that time, neither in cultural manner nor in militaristic one, he went for what was more important.
Answer:
Madison defines a faction as "a number of citizens, whether amounting to a minority or majority of the whole, who are united and actuated by some common impulse of passion, or of interest, adverse to the rights of other citizens, or to the permanent and aggregate interests of the community."
Nixon staffers began to spy on the opposition, including members of the Democratic Party.
Nixon's constant fear resulted in his staffers taking extreme actions to ensure he won. This including developing false rumors about different politicians and even breaking into the Democratic headquarters at the Watergate complex. This paranoia would eventually lead to his downfall, as members of the Committee to re-elect President Nixon were arrested for burglary after trying to steal documents from the Democratic Party.
I don't know exactly what your looking for but, it could do with religion or different ideas of the country.
For example: Let's say that America goes to war with Russia and the Americans didn't want to go to war. The people have a differed idea from the government, meaning that the military does not have the peoples support.
Hope it helps!