The Compromise of 1850 included a much harsher fugitive slave law. It also comprised all of the following, with the exception of Kansas, which joined the Union as a slave state.
A new, more stringent Fugitive Slave Law Congress enacted a harsh fugitive slave statute, requiring authorities in all states and territories to help in the recapture of enslaved persons who had fled to freedom or paid a significant fee.
As the political confrontation between abolitionists in the North and slaveowners in the South escalated, Congress approved the Fugitive Slave Act of 1850, which imposed tougher sanctions for interfering with slaveowners' recovery of runaway slaves.
The legislation jeopardized the safety of all blacks, slave and free, and caused many Northerners to become more outspoken in their support for fugitives.
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Economic productivity has declined in some countries as a result of : Bubonic Plaque
In the past, Bubonic plaque manage to kill about 25 - 30 % of the world population, these greatly decrease the number of workers that could contribute to production activity and reduce Overall economic productivity in several countries
Without having a timeframe or choices, I would guess it would be the Holocaust which was from 1941-1945 when the German Nazi's rounded up and excecuted Jews (men, women, and children)
The Constitution The Emancipation Proclamation
