Question

What is mayfield in 22 mean

Answer 1

The episode is about the men when the two actors talk about it and said to set up an appointment in May field 22. The office of Dr.jason mayfield, ED specialist in erectile dysfunction

Answer 2

So, I'm assuming you're talking about Grey's Anatomy, yeah? If so, It is about Dr. Mayfield, an erectile dysfunction specialist, whose office is Number 22. Thus, "I've got an appointment with Mayfield in 22."