Cómo es ella? because you need the same verb as the answer (between ser and estar) and cómo means how. The answer is about how the girl is, so it is the right question
De d<span>ónde means where so it wouldn't be good.
Also C</span><span>ómo se llama? means what's her name which is not given in the answer.</span>
Answer:
ok muchas gracias por tus puntos
Mis primos son muy _______________
Answer : cómicos
Mi abuela es muy __________________
Answer : amable
Mis hermanas son muy ___________________
Answer : generosas
Mi papa es ____________________
Answer : alto
Mi madrastra es ____________________
Answer : bonita
Hope this helps!