This is the location that has the greatest chance of escaping the bubonic plague. The reason is that this location is not near any major trade route. Trade routes were dangerous during this time period because they were areas where many different people from different places interacted. This meant that the risk of spreading the disease was larger. Therefore, towns that were located along major trade routes were the first ones to be badly affected by the disease.
Suppose your ancestors came from the Highlands of Western England and settled in the Appalachian Mountains of present-day West Virginia. Among the waves of immigrants from England your ancestors were the D) Puritans.
By contrast the Federalist party of Hamilton favored a loose or broad construction of the Constitution, which would allow the expansion of federal government power to meet important needs of national scope.