The answer you are looking for is that makes them seem guilty.
The flight of Duncan's sons play into Macbeth's hands making them seem guilty, making it look as if they left the country because they were guilty and don’t want to be caught.
This helped Macbeth because as long as everyone thinks the sons did it, nobody is suspecting Macbeth. Macbeth kills the chairman, and he admits it saying he did it out of rage, making Duncan's sons more scared of him.
Duncan is a king and he has two sons. The sons were <span>Malcolm and Donalbain. </span>The flight of Duncan's sons portray into Macbeth hands is that, he killed the chairman, and that it was done because of anger. This reason made Duncan's son feared him more and more.