Kara, the girl with the bleached hair and the spray-tan, is going to Rubio´s for lunch.
Explanation:
In this case, the comma is used as an interrupter. They are little thoughts that pop up in the middle of a sentence, they add extra information to the sentence but could be removed without changing its meaning.
In this case, it adds the description of Kara but if you removed the statement between the commas the sentence would be completed anyway.