The way that religious differences affected the middle east is :
They have caused much conflict
They even had conflicts between groups from the same religion but with a different point of view
hope this helps
I'm pretty sure (1.) is A, and I know for a fact that (3.) is D because slavery was a regular practice between quarreling tribes. I have no clue what (2.) is. Best of luck.
C. It uses totally opposite suggestions to get what you want