Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Hello <span>Circe2633 </span><span>
Answer: A file must be opened before data can be written to or read from it. closed opened buffered initialized none of these
Hope this helps
-Chris</span>
I think if a large number are accessing at the same time you would have to wait for many to clear up
Answer:
C: Nothing
Explanation:
Assuming this case is acting upon a switch on an integral value, there is nothing wrong with this case header.
var x = 10;
switch (x)
{
case 2:
Console.WriteLine("The value of 'x' is 2!");
}
