The correct answer to this open question is the following.
The regional differences in the social aspects of republicanism given the national scope of other republican inspired developments were important in the definition of the country. Republicanism has guided the policy of the United States since the times of the American Revolutionary War. These ideas had the influence from other nations ideas such as the Greeks, the Romans, and the Enlightenement. They are based on liberty and justice. That is why Republicanism ideas have defended the civil rights and liberties of many Americans, although have been interpreted in dofferent times by diferent people as was the case of slavery in the South before, during, and after the Civil War. Or the rights of women in the 1900s.
In the southern part of republican, many property ownership that exist was slave based. Meanwhile, the northern republican tend to rely on industrial development. This was the main differences of the regional republican
The main impact De Soto's expedition was disease.The Native Americans did not have any immunity to European diseases since they had never been in contact with them. The most detrimental of illness was the smallpox. They also were introduced to animals such as horses, war dogs, and pigs.