Answer:
sugar cocoa ivory oil tea and rubber pieces
Generally speaking, westward migration had a very negative impact on the Indian's way of life, since a large majority of Natives were either displaced from their homes or killed in order to make way for white settlements.
The exact date is unknown but between 550 bc and 539 bc.
B. and E. marked the downfall of the Inca empire, for obvious reasons. Disease and civil war would obviously kill the empire, and taking an important leader would also mark great chaos within the empire. A. and C. are not to be ignored however, considering that maintaining peaceful relationships with the Spaniards only brought death and chaos to the Aztecs, all from the Spaniards.