The correct answer is A. Slavery was not an issue
In the beginning of the 1800's slavery was still a big thing in the south even though the North disproved of it. That is one of the main reasons why the civil war was fought and why the emancipation proclamation was made to free the slaves from rogue states.
C. the closing of the First Bank of the United States
The Republican Isolationists refused to ratify President Wilson's League of Nations plan because D) they were opposed to Article 10 that could infringe upon the United States' right to declare war and expand its territories.