C. Causation involves one event that leads to the occurrence of another.
Explanation:
As per the Bureau of Statistics connection is, "A statistical measure (expressed as a number) that describes the size and direction of a relationship between two or more variables."
While causation "Indicates that one event is the result of the occurrence of the other event; i.e. there is a causal relationship between the two events. This is also referred to as cause and effect."
The cause of the Encomienda system was the Spanish crown offering land and Indian slaves to conquistadors going to the new world. The effect was heavy depopulation of Indians from brutality and disease leading into African slaves becoming a new labor force.