OBJECTIVES: To analyze the occurrence and types of neoplasias that have developed in patients submitted to orthotopic heart transplantation in the Cardiac Transplantation Program of the Paulista School of Medicine, Federal University of São Paulo.
METHODS: The present study presents an observational analysis of 106 patients submitted to orthotopic heart transplantation from November 1986 to September 2002, who survived for more than 30 days after the procedure. The immunosuppressive regimen consisted of triple therapy with cyclosporin A, azathioprine and corticosteroid. Only two patients received, in addition to triple therapy, the addition of orthoclone OKT-3. The mean follow-up period was 61.4 months. (variation from two months to 192 months).
RESULTS: Twenty-three patients (21.3%) developed neoplasias, of which 56.5% had skin neoplasms, 30.1% had solid tumors and 13.4% had post-transplantation lymphoproliferative disease (PTLD). The mean interval between transplantation and the diagnosis of neoplasia was: skin - 54.9 months, solid tumors - 24.8 months and DLPT - 70.3 months.
CONCLUSIONS: The occurrence of malignant neoplasms was relatively common in the analyzed population. Skin cancer prevailed in relation to other neoplasms and solid tumors were more diagnosed than lymphoproliferative diseases in this series of patients.
Answer:
Yes it's possible but It would sound better If you said, positive and negative emotions.
Explanation:
Desirable and undesirable can have conflicting meanings I.e desirable is what you like and undesirable is what you don't like but you can desire something negative or have something good that's undesirable to you.
It influences a lot because, as the story is evolving so is the setting.
It matters because, without setting there's no story.
I believe that setting is the most important part of a story because, it tells u many things..
For Example :
TIME /PLACE /BACKGROUND OF STORY /AND WHERE SOMETHING TAKES PLACE..
in the house, park, pools, hotels, movies, Etc....
I believe the answer is Disarranged. meaning it was sloppy, and scattered
