Honestly I think you should look the words up in a Spanish dictionary. If you don't have one go get one. Whatever you do don't use google translate. It doesn't translate exactly right. You can use google translate for reading something in Spanish but never to write something.
Answer:
¿Cómo <u> Está </u> tu tío? Está <u> Cansadísimo </u> y enfermo.
I think it’s b because it makes more sense
