It could possible be ironic and problematic because the rest of the world was technically already "discovered", but just not by the Europeans specifically.
I cant quite put it, but lots of people died from each side. I'm going to guess negative and here is my starting sentence.
The Spanish-American war was negative because lots of men, and women died from both sides.
I'm going to let you copy the sentence above for your TOPIC sentence. I hope this helped, but you need to know the rest.
Answer:
Economically, the population decrease brought by the Columbian Exchange indirectly caused a drastic labor shortage throughout the Americas, which eventually contributed to the establishment of African slavery on a vast scale in the Americas.
Explanation: