Question

During replication which enzyme relieves the tension created by the unwinding of the dna duplex?

Answer 1

Answer:

ENZYME TOPOISOMERASE RELIEVES THE TENSION CREATED BY THE UNWINDING OF THE DNA DUPLEX.

Explanation:

During replication, the DNA structure undergoes unwinding which is the unfolding of the DNA structure for transcription to take place is performed by an enzyme called Helicases. Topoisomerase are involved in relieving the tension caused by unwinding of the intertwined DNA because the DNA becomes overwound and can stop the actions of DNA or RNA polymerase needed in transcription of the DNA sequences. Topoisomerase binds to the DNA and creates breaks in the DNA which allows for easy unwinding and these breaks can later be resealed after replication as taken place. Two classes are topoisomerase are known; the toposisomerase type 1 which cuts a strand of DNA and allows for relaxation to occur then the re-ligation of the cut strand, it doesn't utilize the ATP for hydrolysis and are grouped into 3 namely Type 1A , Type 1 B, type 1 C; the second class of topoisomerase is type (II) topoisomerase which cuts both strands of a DNA, omits and pass an unbroken strand and then re-ligate the broken strands. It uses ATP for hydrolysis and are of two types; type II A, type II B.