Answer:
C.The added epitope disrupts the function of the tagged protein
Explanation:
When an additional sequence is tagged to a protein to use comercial antibodies, there are several reasons why this procedure wouldn't work as expected (note that we're assuming the protein is being expressed but it's not possible to detect it).
For example, the sequence of nucleotide added to codify for the tagged epitope are removed during the RNA processing. In that case, the protein would be expressed without the epitope, so it would be impossible to localize it with the antibodies.
Also, it could be that the new epitope is affecting some way the protein folding, making it not functional. This way, it would be degraded by the cell so it wouldn't be detected.
Another possibility is that the epitope doesn't affects the protein folding nor its function, but during the folding ends up in a conformation that makes it inaccesible for the antibody.
In summary, the way as the possible answers to this question are shown, the correct option seems to be C:<em> The added epitope disrupts the function of the target protein.</em>
Answer and Explanation:
The hypothalamus contains the central thermoreceptors which detect blood temperature as well as the thermoregulatory centre. The skin of organism contains peripheral thermoreceptors which detect the environmental temperature.
Increase in body temperature above the normal initiates the appropriate corrective mechanisms that include sweating, lowering of hair for mammals, vasodilation of superficial blood vessels and decrease in metabolic rates. This has an overall effect of causing the body temperature to fall and the normal body temperature is restored.
Sweat is secreted by sweat glands that evaporates from the surface of the body cooling the body as it absorbs latent heat of vaporization. Superficial blood vessels vasodilate so that more blood flows near the surface to encourage heat loss. Hair is lowered so that it lies against the body surface. This encourages heat loss from the body to the external environment.
Functionalism. It is according to the concept 'survival of the fittest'
