Genes are segments of DNA located on chromosomes. A gene mutation is defined as an alteration in the sequence of nucleotides in DNA. This change can affect a single nucleotide pair or larger gene segments of a chromosome. DNA consists of a polymer of nucleotides joined together. During protein synthesis, DNA is transcribed into RNA and then translated to produce proteins. Altering nucleotide sequences most often results in nonfunctioning proteins. Mutations cause changes in the genetic code that lead to genetic variation and the potential to develop the disease. Gene mutations can be generally categorized into two types: point mutations and base-pair insertions or deletions.
Answer:
The nuclear receptor superfamily comprises a large group of transcription factors that play a key regulatory role in development and homeostasis of multicellular organisms. A special feature of nuclear receptors is their ability to bind to condensed chromatin templates, which makes them important initiators of gene transcription. Moreover, the ability of nuclear receptors to sequentially recruit a variety of transcription factors and coregulators to target promoters and to orchestrate the whole process of gene transcription confirms their biological significance and stimulates intensive research and a high level of scientific interest in this field. In this review, we summarise current knowledge regarding the structure and function of nuclear receptors as principal regulators of gene expression. Emphasis is given to the molecular mechanisms of nuclear receptor-mediated transcriptional activation and repression including recent progress made in this area.
Answer:
The fall made animals and plants affected by disease. It was hard to get food,many things died and it also made some animals into carnivores.
Water drains into the sinkhole pollution due to factories
The lake was created as limestone gradually dissolved, causing the sediment layer above it to collapse and creating the lake basin. Low lake levels and slow draining can be caused by bottom leaks, sinkholes, and swallets, long-term dryness, and a lack of recent, strong rainfall events.
<h3>What causes lake Jackson to disappear ?</h3>
Before the lake dried up, those walking along the shore of the sinkhole at Lake Jackson on Thursday would have been in three to four feet of water.
- Environmentalists refer to the process as a "dry down," and it occurs every ten or twenty years. The likelihood of causes includes dry weather, a lack of rain, and a decreased water table.
- The lake will typically begin to fill again after the sinkhole plugs itself, sometimes taking years to do so pre sinkhole level
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Water cause increase growthpf algal bloomand green plants
