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The part that particularly angered Northerners was that if they did not enforce the act, they were subject to jail time or a fine. Even if Northerners opposed slavery, they could still be neutral in terms of what they do to help slaves or not. The Fugitive Slave Act forced them to go against their own beliefs with this potential jail time or fine, which really angered them.
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The exchange that most affected the indigenous people was the one of diseases. Native Americans hadn't encounter the diseases the European brought before, so they hadn't develop immunity to them. This is the major reason of the large death of Native Americans, besides the war between them and the brutality of the Europeans.
Ronald Reagan was the first American president who was able to stop the Cold War. This became his strongest legacy. He was able to restore peace with the Soviet Union as he and the Soviet Union President Mikhail Gorbachev was able to set a peaceful resolution during the summit.