The most likely explanation to the statement that digestive enzymes released in your mouth break down carbohydrates there but stop working in your stomach is C. The pH of your mouth and stomach are very different. The shape of the enzyme is affected by pH.
The pH of the mouth is near neutral whereas the pH of the stomach is acidic due to the hydrochloric acid present in the stomach.
All enzymes, including the digestive enzymes, require a certain pH at which they are better able to function. If the pH is altered, then the shape of the enzyme changes, which affects the shape of the active site of the enzyme. As a result, the substrate is no longer able to fit in the active site.
Hence, those digestive enzymes that function in the mouth will not function in the stomach due to the altered pH.
Although a part of your question is missing, you might be referring to this question:
Digestive enzymes released in your mouth break down carbohydrates there but stop working in your stomach. which is the most likely explanation?
A. Enzymes have only one active site. Once a substrate binds, that enzyme is no longer usable.
B. Enzymes are changed in a reaction. Enzymes made in the mouth are used up by the time they get to the stomach.
C. The pH of your mouth and stomach are very different. The shape of the enzyme is affected by pH.
D. There are no substrate molecules left when the enzyme reaches the stomach, so the enzyme stops working.
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