your answer is a hope this helps
A mutation in human ATPase 6 from leucine to
arginine at position 156 may allow the movements of protons across the
membrane, but not rotating of the ring of c subunits.
This possible mechanism affect the function of
ATP synthase because there would be an uncoupling of proton translocation and ATP
synthesis. ATP synthase would remain sensitive to F0 proton conduction
inhibitors
Purpose and Research to form your hypothesis
