Answer:
B. He was a German mathematician and astronomer who established a set of laws to describe planetary motion around the sun.
I believe the answer is it committed the colonies to being independent.
A) A fort was established and many were killed by diseases
Lewis and Clark's expedition was not positive to the native of Mandan village the most devastating epidemic was the smallpox outbreak in the year 1837 killing a lot of people. The epidemic played an important factor in uniting the surviving Mandans and Hidatsa who later engaged in trade, farming and hunting.
A)build roads and enforce laws