Throughout the history we can see a trend of giving citizenship to more and more people, rather than just to elites. For example, in the early stages of history only men possessed citizenship, and also significant portions of societies did not have the country's citizenship, such as in the case of slaves.
On September 30, 1788, Pennsylvania became the first state to elect its two senators. On March 4, 1789, the first group of elected senators reported for duty. From 1789 to 1913, when the Seventeenth Amendment to the U.S. Constitution was ratified, senators were elected by state legislatures.
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When glucose levels are low, cAMP is produced. The cAMP connects to CAP, letting it bind DNA. CAP permits RNA polymerase fix to the promoter, resulting in high levels of transcription.
<h3>What happens to cAMP when glucose is low?</h3>
When the concentration of intracellular glucose is low (upper panel), the classes of the signal molecule cAMP are high. cAMP readily binds with CAP, and the CAP-cAMP complex binds DNA at a standing upstream of the lac operon.
<h3>How does glucose connect with cAMP in the lac operon?</h3>
Once the glucose is used completely, the adenylate cyclase is not inhibited anymore and thus can produce cAMP, which constructs a complex with the catabolite activator protein (CAP) and thus permits the transcription of the lac operon.
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Warm Springs, Georgia was the site of President Franklin D Roosevelt's "Little White House".