Though Texas wanted to be annexed and had voted within their independent nation to become a part of the US, Mexico had still not settled Texan independence and therefore was upset by the US's move to annex Texas. There were many boundaries unsettled after the Texan Revolution and this will lead to issues between Mexico and the US in determining the border. These border disputes coupled with contempt for US actions will lead to the Mexican-American War in 1846. This war will end with Mexico losing all of what is now the SW of the US in 1848 under the Treaty of Guadalupe Hidalgo.
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It was David Livingstone who was the first to cross the African continent. He did so under great amounts of danger and would eventually die a mysterious death in Africa.
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The worst negative effect of the Columbian exchange was the disease which brought to the people of New World such as smallpox, measles, chicken pox, malaria, influenza, and cholera
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