The US Constitution established the Federal system of government. The best way to describe the Federal system of government is that it is a shared power of government between the nation and the states.
Before Missouri joined the Union, the free and slave states were equally balanced in congress.Missouri wanted to join as a slave state, so the balance would be upset.
I am unsure about John McCain but but I know Obama was the only president born outside of the 48 consecutive states (he was born in Hawaii). I believe John was as well.