Charles V was known for being a ruler of the Holy Roman Empire. He wanted to unify and create a huge empire but was thwarted because of the Protestant reformation. So he abdicated and gave them throne to his son Phillip.
It was the failed Bay of Pigs invasion conflict with Russia over missiles in Cuba active U.S. involvement in Vietnam
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Hernando de Soto was a Spanish explorer and conquistador who participated in the conquests of Central America and Peru and discovered the Mississippi River.
I can't answer your second question since I know nothing about it, my apologies, but I hope that this will help answer about Hernando de Soto.
Compounding is one of the challenges faced by developing countries in regards to health care. The WHO plays a big part in these challenges, because there needs to be a person or group with a stable financial situation to donate or offer help. If someone who does not have any power or money help, there is a less likely chance in making a difference in regards to the problem.
Became the first European mariner to round the southern tip of Africa, opening up a sea route from Europe to Asia.