The histone acetylation catalyzed by histone acetyltransferases and deacetylation catalyzed by histone deacetylases performs a significant role in the regulation of the expression of genes in eukaryotes. Histone acetylation diminishes the affinity of histones towards DNA leading to relaxing or decondensation of chromatin and becomes accessible to the transcriptional apparatus and to perform transcription.
It can be stated that histone acetylation is related to expression or gene or activation and histone deacetylation is related to the inactivation of gene or repression.
