D. sixteen nations
The International Space Station (ISS) is the biggest space station ever constructed, the largest structure ever congregated in space, and one of the most complicated global experimental projects in history.
The United States, with the help of NASA, commences the ISS project, by involving 15 other nations in construction and operating several parts of the station. The nations involved are Russia, Canada, Japan, Brazil, and 11 member countries of ESA (Belgium, The Netherlands, Norway, Spain, Sweden, Denmark, France, Germany, Italy, Switzerland, and the United Kingdom.