<span>A drug used to treat CML, imatinib, binds to the active site of Abl kinase. Why does this drug work to treat this type of cancer?
</span><span>B) By binding to the active site, the drug prevents the ability of Abl kinase to bind to its substrate.
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Imatinib works against CML by binding close to the ATP binding site of bcr-abl. The binding results to the<span> locking in of the bcr-abl to a closed or self-inhibited conformation and inhibiting the enzyme activity of the protein </span><span>semi-competitively.</span>
Answer: c. proteasome
Explanation:
Proteasomes are extremely important multi-catalytic proteases and are involved in various cellular functions. The proteasome is an essential component of eukaryotic cells and is responsible for the ATP-dependent proteolytic degradation of most cellular proteins. They are present in the nucleus and cytosol and can represent up to 1% of total cell proteins. Proteasomes generally degrade proteins to small peptides, most of which are rapidly hydrolyzed by cytoplasmic exopeptidases. It catalyzes the rapid degradation of many enzymes, regulatory proteins, and eliminates abnormal proteins resulting from mutation or damaged proteins. The inability of this cellular organelle can lead to neurodegenerative diseases, such as Parkinson´s disease.
Answer:
By changing a gene's instructions for making a protein, a mutation can cause the protein to malfunction or to be missing entirely. When a mutation alters a protein that plays a critical role in the body, it can disrupt normal development or cause a medical condition.
Answer:
The Answer is c. Mitosis: Eukaryotic Cell Division and Cloning Specialist.
Explanation:
Mitosis means when a cell divides into two cells. As cells divide, the number of cells doubles. And each cell is an exact duplicate of the original cell, or a clone. Eukaryotic means that everything in the cell is enclosed in a membrane.
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