The eukaryotes translation process requires two more step known as polyadenylation and capping. The transcription and translation occurs in the separate compartment.
The eukaryotes genome consists of both the exons as well as introns. The introns need to be excise out and exons join together in the process known as alternative splicing. This alternative splicing is responsible for the formation of the different protein.
If you have 20% of contracting the disease it wouldn’t be that dramatic but if you have 50% it’s pretty bad I think you won’t be able to see the person with 20 only 50 would have symptoms