changes to the mutation is harmful
mutations are basic input of a organism
so playing with mutations is like inviting danger
it will give beneficial and neutral defects to the organism and may take life of it.
the biggest example is playing with virus which caused corona
I am pretty sure the best answer that I can give you is Aristotle, based on my previous knowledge of the topic. Have a great day.
the answer is 4
the Panhandle, North Texas, South Texas, and West Texas.