As we know....the Roman Empire was very, very successful.....but if we look closely; I believe it's quite easy to distinguish by which means the Roman Empire used to grow. Rome just loved to war aka conquest other countries...it would use its resources and force them to pay tributaries (payment to the person whom conquered them). They had an incredibly good army..their military techniques were incredibly smart..and they also had war machines; which greatly contributed to their power on the battlefield. As far as I know, Rome rarely made alliances and agreements...Christianity was after the fall of Rome.
This being said to expand and grow, it's quite obvious that the Roman Empire went on conquests and war to expand and thrive. Alas, all Empires fall...as did the might Roman Empire.
B- The people did not have immunity against the disease. Smallpox had not been introduced to that region before so the people there were not adapted to it, and their immune systems weren’t able to fight it. This was used as biological warfare by the european settlers.