While settlers traveled west along the Oregon Trail for a variety of reasons, most were motivated either by land or gold. Various land acts in Oregon provided free land to pioneers, while the start of the California Gold Rush in 1848 lured thousands more.
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What was common is that they were both fought as plans of Lee to move the fighting no Northern Parts of the federation. Antietam ended in a draw, while Gettysburg became a victory for the Union.