The holy lands are located in Jerusalem and it's important because so many events happen there such as the birth of Jesus and it was the place Jesus, the Messiah came to save all the people
Well, the moment the US intervened with the affairs of the World was the moment that the US could not go back to an isolationist policy. The US simply cannot afford to stop playing a role in world affairs, due to the fact that the US is a capitalist society and that the US has a lot of exports/imports. Unless the US can reach a level of capacity where it is self sufficient, which is currently impossible to do, the US must participate in the affairs of the World in order to survive.