Question

Which of the following is correct with regard to HIV infection? A The host cell receptor is GP120 which the viral spike protein CD4 will bind to. B The host cell receptor is CD4 which the viral spike protein GP120 will bind to. C The host cell receptor is CCRR which the viral spike protein GP41 will bind to. D The host cell receptor GP41 will bind to the viral sprike protein CCR5.

Answer 1

Answer:

B The host cell receptor is CD4 which the viral spike protein GP120 will bind to.

Explanation:

In HIV binding and entry, the HIV protein envelope, glycoprotein GP120 binds to the host primary cellular receptor CD4 to fuse to the host cell membrane and then initiate infection.

The virus presents itself as viral membrane spikes (molecular mimics of host molecules), these spikes consist of three molecules of gp120 which are linked together and anchored by gp41 protein to the membrane. The gp120 then binds to CD4 receptor of the host cell to facilitate viral entry int the host cell and further illicit other responses that lead to infection and dominance.