Question

Ou have screened for several new recessive mutations in a species of wasp. wasps homozygous for apricot (aa) have pale orange eyes. (wild-type eyes are brown.) wasps homozygous for blunt (bb) have short wings. (wild-type wings are long.)

Answer 1

Mutation in the gene encoding the recently isolated WASP protein has now been identified as the genetic defect responsible for the X-linked Wiskott-Aldrich syndrome (WAS), a primary immunodeficiency disease associated with extensive phenotypic variability.

Answer 2

The non-recombinant gametes are AB and ab which are found in the parents whereas aB and Ab are recombinant in nature as they are absent in parent genotype.

Further explanation:

The true-breeding or pure-breeding represents the parents that are homozygous in nature and will pass on the specific trait to the progeny as they contain either recessive or dominant alleles but not both. The parents heterozygous for a trait will not be able to produce exactly the same phenotype in the offspring due to the presence of both types of alleles.  

The genotype of pure-breeding double-mutant can be depicted as ‘aabb’ for apricot and blunt while the wild-type genotypes can be considered ‘AABB’. The cross between the mutant and wild type genotypes would result in the progeny with only ‘AaBb’ genotype.

Parent:   aabb × AABB

Filial 1 (F1) generation: AaBb

The F1 hybrids are then test crossed with double-mutant line and result as follows:

AaBb × aabb

 F2 generation:

The genotypes obtained in the F2 generation are AaBb, Aabb, aaBb, and aabb which have the phenotypes wild-type, wild-type apricot, pale orange-wildtype, and double-mutant, respectively.  

AB, Ab, aB, and ab are the haploid genotypes that were received as gametes from the F1 generation. The gametes Ab and aB are considered recombinant while gametes ab and Ab are said to be non-recombinant because the recombinant gametes are not found in the parents while the non-recombinant ones have been transferred from the parents.

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Answer details:

Grade: College Biology

Subject: Genetics

Chapter: Gene Interactions

Keywords:

Gametes, recombinant gametes, non-recombinant gametes, pure-breeding, true-breeding, F1 generation, F2 generation, genotypes, phenotypes, recessive allele, dominant allele, wild-type, mutant.