Answer:
The correct answer is option b. "cause a change in the reading frame of mRNA codons".
Explanation:
Frameshift mutations are among the most drastic mutations because in most cases, result in the translation of a completely different protein. Frameshift mutations are the result of insertions or deletion of one or more nucleotides, resulting in a change in the reading frame of mRNA codons. In consequence, the ribosome translates a different amino acid sequence, based on the new reading frame of mRNA codons.
I do not understand your question fully because there might be some context missing to it:
Having more nuclei is not something caused by the lack of a process or stage. Some muscle cells usually fuse together, which means they become one. But before they became one, each had their own nuclei. And when they fused, each one kept their nuclei, making one cell with more than one nuclei.
Those cells are called multinucleated cells.
Hope it helped,
BioTeacher101
Maybe, not sure, may need to check yahoo answers for this one