That would be smallpox hopes this helps -T
Explanation:
In 313AD the Emperor Constantine issued the edict of Milan which accept Christianity
I believe it would have to be the light bulb that destroyed the first market for petroleum.
Hope it helps if I'm right!
The disruption in Atlantic shipping prior to and during the War of 1812 increased the manufacturing and this was the way it affected the United States economy. Since there was problem in importing products, so to balance it, the internal production was increased and this way the economy sustained that period.
The Dark Ages started, named for which for having lack of learning and establishment of feudalism.