All the illnesses that are being passed done generations. Like cancer from all the chemicals and radiation. Or the PTSD that is passed down with the generations. There are a lot of illnesses that can be talked about.
Answer: Settlers and tribes both had effects on each other. On many trails headed west, settlers traveled in fear of attack from tribes who would rob or kill members of caravans. Tribes would attack stagecoaches and wagons that traveled across their lands. On the other hand, settlers constantly encroached on tribes’ lands. When settlers drove cattle, built railroads, established trails, and created new settlements, tribes were driven off of their lands. Often, this happened to tribes that had already relocated from other parts of the country to escape settlement. As the two groups fought over land, tribes struggled to get the resources they needed. While both groups profited from each other, both also were harmed by expansion in different ways.
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I'm not sure about the Hellenistic society, but the Greek Civilization contributed a lot to our world today. Many philosophers like Plato and Socrates still have sayings that are used today. Architeture played a huge role. I'm fairly certain the Greeks named a ton of the constellations.
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I hope this helps a little bit. You can always research more.