The Mongol Empire, with its peak size under the rule of Kublai Khan around the year of 1279, included parts of modern Russia in the North, modern day Korea, and modern China in the South on one end of the Asian continent. It stretched through the Asian continent all the way to modern day Hungary in Europe. It also included parts of the modern Middle East such as Iraq and Iran. The total area of the Mongol Empire in its peak was around 40 million km^2.
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Disease. When the Spanish arrived, they brought with them smallpox. Smallpox spread among the indigenous people and crippled their ability to resist the Spanish. The disease devastated the Aztec people, greatly reducing their population and killing an estimated half of Tenochtitlan's inhabitants.
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