The sign would be negative
Without any calculations it's evident it can't be neither B (both numbers are even, so they're divisible by 2) nor C (the numbers end in 0 and 5, so they're divisible by 5).
A.

Both numbers have a factor of 3, so they're not relatively prime.
That means it must be D. But, let's check it.

Indeed, those two numbers are relatively prime.
I hope this helps you
-4,-3,-2,-1,0,1,2,3,4,5,6
Answer:
4-13=-9
Step-by-step explanation: