Question

What happens when the centrioles stopped working?

Answer 1

It is well known that the centrosome acts as a microtubule organizing center, with its textbook role in forming mitotic spindles in dividing cells. So in many cells, the centrosome with its centrioles is indeed essential to ensure correct cell division, and in these the PCM ensures the distribution of the right number of centrioles to each daughter cell. But there are exceptions – which include somatic cells in fruit flies and some fungi – where no centrioles are needed; and centrosomes in some differentiated cells, including neurons and muscle cells, are inactive.