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mafiozo [28]
3 years ago
15

What characteristics do mutations have ?

Biology
1 answer:
aliya0001 [1]3 years ago
3 0
Some genetic mutations can be completely harmless, while others are life-altering. Mutations happen when DNA is copied incorrectly. This causes an irregularity in the DNA. Mutations are permanent changes to genetic material that can be passed on to offspring. These changes happen randomly and can occur in any type of gene. While some mutations are not harmful (hazel eyes, for example), many mutations have harmful effects on health.
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The CRISPR/Cas9 system can cleave genomic DNA at sequences other than the desired target, a phenomenon referred to as off target
Deffense [45]

Answer:

The minimum length of a sgRNA sequence to avoid off target cleavage by the CRISPR/Cas system in the fly fruit genome is 14 bases

Explanation:

We are trying to use the CRISPR/Cas system to cleavage the genome of the fruit fly (which is 1.4x10^8 bp long). Also we desire the cleavage to be unique. That means we need a target sequence long enough to be able to assume it will only appear once in the genome.

First, we should think that in every position, we can find one out of four different nucleotide (A, C, T, G). So, the probability of getting a sequence of a given length "n" will be (1/4)^n (We are assuming that the probability of finding a nucleotide in the position "i", it's independent of the nucleotide we find in any other position "j").

Also, to know how many times a sequence will appear in a genome (the expected value of occurrence), we must multiply the probability of that sequence to randomly occur by the length of the genome. For our specific example, the number of occurence of a sequence of length "n" is:

nºoccurence=[(1/4)^n]*1.4*10^8

But in this case, what we want is the expected number of times the sequence will appear to be 1, and we want to obtain the length of the target sequence (n).

Given the information above, we know that:

[(1/4)^n]*1.4*10^8 =1

[(1/4)^n]=(1/1.4*10^8)=1.4*10^-8

Then, if we want to calculate n, we can use logarithms and its properties to get:

log[(1/4)^n]=log[1.4*10^-8]

n*log[(1/4)]=log[1.4*10^-8]

n=log[1.4*10^-8]/log[(1/4)] => n=13.29 approximately.

As the sequence needs to have a natural number of elements, <u>we can conclude that using a target sequence of a minimum of 14 bases with the CRISPR/Cas system in the fly fruit genome should be enough to avoid off target cleavage.</u>

3 0
3 years ago
Which component of blood allows oxygen from the air to move from the lungs to cells of the body?
Margarita [4]
D) Red Blood cells
4 0
3 years ago
Read 2 more answers
Does social distancing increase or decrease your carbon footprint?
Andrej [43]

Answer:

Decrease

Explanation:

The carbon footprint is <u>the amount of carbon (in terms of greenhouse gases) being emitted by human activities</u>. In a situation where <u>social distancing is encouraged, human activity would reduce significantly</u>. Very few people will be outside and the causative agents of pollution (anthropogenic) will be significantly reduced. Further, nature would be able to minimize the impacts of pollution when human activities are less than the threshold capacity.

Let's take an example of coronavirus spread globally this year. The social distancing of 2 meters has significantly reduced the number of people going outside. Ultimately, there are fewer automobiles on the roads and a few industries are running. The result is that the air quality index has been significantly improved. For example, in India, people from 300 km away, can see the Himalayan mountain range very clearly (see image attached). This has not happened in decades after modern industrialization.

4 0
2 years ago
What is the main difference between the central nervous system (CNS) and the peripheral nervous system (PNS)?
Paladinen [302]
The CNS involves the brain and spinal cord and the PNS involves the body nerves.
6 0
2 years ago
Read 2 more answers
What distribution of phenotypes would be expected for a polygenic trait?
rewona [7]
 The number of phenotypes produced for a given trait depends on how many genes control the trait. Anyhow, The distribution of phenotypes for a typical polygenic trait can often be expressed as a bell-shaped curve.

Many traits are controlled by two or more genes and are, therefore, called polygenic traits<span>. Each gene of a polygenic trait often has two or more alleles. As a result, one polygenic trait can have many possible genotypes and phenotypes.</span>
4 0
3 years ago
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