Question

Two proteins associated with a rare neurodegenerative disorder have been sequenced. Protein A contains many polar amino acids with small regions containing nonpolar, hydrophobic amino acids. Protein B is rich in nonpolar, hydrophobic amino acids with only two small regions containing polar amino acids. What might this suggest about the two proteins?

Answer 1

Answer:

Protein A can be a cytoplasmic and protein B can be a membrane protein.

Explanation:

The polar amino acid will have the hydrophilic side chain so they provide the hydrophilic nature to protein and thats why usually found on outer surface of water souluble proteins.

Cytoplasm is 80% water, so these proteins usually found in cytoplasm.

The non-polar amino acid will have the hydrophobic side chain and thus provide hydrophobic nature to protein and usually found in interior portion of membrane protein.

Plasma membrane is made up of hydrophobic lipids bilayer, so these proteins are usually found in plasma membrane.