In both German and Italian unification there was on leading state.
Finally, and most controversially, a Fugitive Slave<span> Law</span>was<span> passed, requiring northerners to return runaway</span>slaves<span> to their owners under penalty of law. The</span>Compromise of 1850<span> overturned the Missouri</span>Compromise<span> and left the overall issue of </span>slavery unsettled<span>.</span>
If I see the document I'd be happy to answer your question:)
I believe the answer you are looking for is Merchantilism. Let me know if I helped any.
The cholera epidemic. The others were factors, but not as serious.