The inputs are glucose and oxygen and the outputs are water and carbon dioxide.
Sickle cell disease has a benefit in malaria infection because it makes the parasites easier to eliminate. This makes a person with sickle cell disease is more likely to survive the malaria infection, which found many in Africa.
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Sickle cell disease has a few drawbacks because it makes the red blood cells less durable, which lead to the destruction of more red blood cells. In normal condition(where malaria doesn't exist like in America), this gene will make the organism less likely to survive than those who don't have the gene.</span>
I looked up your question just now and found this sight that has plenty of answers in it. https://www.britannica.com/place/Appalachian-Mountains
Hope this helps.
