D is the correct answer because, it states “however” and it’s the correct use of a transition word from that form of question.
For number four, you are correct. It was disease carrying mosquitos. That was why the colonists didn't have too many run-ins with the indians since the native american avoided the area for that very reason.
Number five is self-government which is where it is run by the people. So your answer would be Colonial Assembly.