Endocrine glands secrete their hormones directly into the<u> interstitial fluid </u>(blood) rather than using via a specified duct. Major glands of endocrine system include pituitary gland, pancreas, etc. They are the glands which do not use any duct, so thats why they are also known as <u>ductless glands</u>.
Exocrine glands secrete their products onto epithelial surface <u>by the way of a duct</u>. Major glands of exocrine glands include salivary gland, mammary gland, etc.